Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease
Microglial involvement in Alzheimer's disease (AD) pathology has emerged as a risk-
determining pathogenic event. While apolipoprotein E (APOE) is known to modify AD risk, it …
determining pathogenic event. While apolipoprotein E (APOE) is known to modify AD risk, it …
Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD
Functional loss of TDP-43, an RNA binding protein genetically and pathologically linked to
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), leads to the …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), leads to the …
Development of brain organoid technology derived from iPSC for the neurodegenerative disease modelling: a glance through
Neurodegenerative diseases are adult-onset neurological conditions that are notoriously
difficult to model for drug discovery and development because most models are unable to …
difficult to model for drug discovery and development because most models are unable to …
Making gene editing accessible in resource limited environments: recommendations to guide a first-time user
S Goolab, J Scholefield - Frontiers in Genome Editing, 2024 - frontiersin.org
The designer nuclease, CRISPR-Cas9 system has advanced the field of genome
engineering owing to its programmability and ease of use. The application of these …
engineering owing to its programmability and ease of use. The application of these …
Map** multimodal phenotypes to perturbations in cells and tissue with CRISPRmap
Unlike sequencing-based methods, which require cell lysis, optical pooled genetic screens
enable investigation of spatial phenotypes, including cell morphology, protein subcellular …
enable investigation of spatial phenotypes, including cell morphology, protein subcellular …
Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model
Accumulation of advanced glycation end products (AGEs) on biopolymers accompanies
cellular aging and drives poorly understood disease processes. Here, we studied how AGEs …
cellular aging and drives poorly understood disease processes. Here, we studied how AGEs …
ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes
H Lee, S Cho, MJ Kim, YJ Park, E Cho, YS Jo, YS Kim… - Cell Reports, 2023 - cell.com
Recent developments in genome sequencing have expanded the knowledge of genetic
factors associated with late-onset Alzheimer's disease (AD). Among them, genetic variant ε4 …
factors associated with late-onset Alzheimer's disease (AD). Among them, genetic variant ε4 …
Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis
Organelle transporters define metabolic compartmentalization, and how this metabolite
transport process can be modulated is poorly explored. Here, we discovered that human …
transport process can be modulated is poorly explored. Here, we discovered that human …
Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes
Gain-of-function mutations in the LRRK2 gene cause Parkinson's disease (PD), increasing
phosphorylation of RAB GTPases through hyperactive kinase activity. We find that LRRK2 …
phosphorylation of RAB GTPases through hyperactive kinase activity. We find that LRRK2 …
The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism
Summary The Foundational Data Initiative for Parkinson Disease (FOUNDIN-PD) is an
international collaboration producing fundamental resources for Parkinson disease (PD) …
international collaboration producing fundamental resources for Parkinson disease (PD) …