The spectrum of inflammatory responses

R Medzhitov - Science, 2021 - science.org
Inflammation is an integral part of animal biology. It provides critical protection from adverse
environmental factors by enforcing the defense of homeostasis and the functional and …

Single-cell atlases: shared and tissue-specific cell types across human organs

R Elmentaite, C Domínguez Conde, L Yang… - Nature Reviews …, 2022 - nature.com
The development of single-cell and spatial transcriptomics methods was instrumental in the
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …

[HTML][HTML] Molecular and spatial signatures of mouse brain aging at single-cell resolution

WE Allen, TR Blosser, ZA Sullivan, C Dulac, X Zhuang - Cell, 2023 - cell.com
The diversity and complex organization of cells in the brain have hindered systematic
characterization of age-related changes in its cellular and molecular architecture, limiting …

Obese visceral fat tissue inflammation: from protective to detrimental?

H Kolb - BMC medicine, 2022 - Springer
Obesity usually is accompanied by inflammation of fat tissue, with a prominent role of
visceral fat. Chronic inflammation in obese fat tissue is of a lower grade than acute immune …

Nanotechnology's frontier in combatting infectious and inflammatory diseases: prevention and treatment

Y Huang, X Guo, Y Wu, X Chen, L Feng, N **e… - … and Targeted Therapy, 2024 - nature.com
Inflammation-associated diseases encompass a range of infectious diseases and non-
infectious inflammatory diseases, which continuously pose one of the most serious threats to …

CRISPR screens decode cancer cell pathways that trigger γδ T cell detection

MR Mamedov, S Vedova, JW Freimer, AD Sahu… - Nature, 2023 - nature.com
Abstract γδ T cells are potent anticancer effectors with the potential to target tumours
broadly, independent of patient-specific neoantigens or human leukocyte antigen …

Emerging functions of IL-33 in homeostasis and immunity

GK Dwyer, LM D'Cruz… - Annual review of …, 2022 - annualreviews.org
Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …

Sensitive activatable nanoprobes for real‐time ratiometric magnetic resonance imaging of reactive oxygen species and ameliorating inflammation in vivo

X Li, Y Liu, X Qi, S **ao, Z Xu, Z Yuan, Q Liu… - Advanced …, 2022 - Wiley Online Library
Imaging‐guided real‐time monitoring of the treatment process of inflammatory diseases is
important for the timely adjustment of treatment planning to lower unnecessary side effects …

The emerging era of cell engineering: Harnessing the modularity of cells to program complex biological function

WA Lim - Science, 2022 - science.org
A new era of biological engineering is emerging in which living cells are used as building
blocks to address therapeutic challenges. These efforts are distinct from traditional …

Social Safety Theory: Conceptual foundation, underlying mechanisms, and future directions

GM Slavich, LG Roos, S Mengelkoch… - Health psychology …, 2023 - Taylor & Francis
Classic theories of stress and health are largely based on assumptions regarding how
different psychosocial stressors influence biological processes that, in turn, affect human …