Protein kinases play pivotal roles in various biological functions, influencing cell
differentiation, promoting survival, and regulating the cell cycle. The disruption of protein …

Despite many decades of research, pancreatic ductal adenocarcinoma (PDAC) remains one
of the most difficult cancers to diagnose and treat effectively. Although there have been …

Cancer is a multifactorial disorder with extremely complex genetics and progression. The
major challenge in cancer therapy is the development of cancer resistance and relapse …

Synthesis of hybrid molecules via molecular hybridization technique has been known to be
a promising strategy which involves the blending of two pharmacophoric groups joined via …

The use of tyrosine kinase inhibitors (TKIs) has resulted in significant occurrence of
arrhythmias. However, the precise mechanism of the proarrhythmic effect is not fully …

Previous studies have revealed the essential role of lysosomes in human diseases,
including cancer. However, there is a lack of in-depth systematic research on its function in …

Background Tumor recurrence or metastasis after surgery is a significant factor influencing
bladder cancer (BC) prognosis. Novel molecular biomarkers are necessary to determine …

After a decade of approval of the drug vemurafenib in 2011, the hopeless scenario imposed
by some severe cancer types has been mitigated by the magic bullets developed through …

Diversity and versatility are the two main reasons behind this special issue proposal. In the
human genome, 518 kinases express different proteins that regulate a variety of cellular …