Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

The human immune system displays substantial variation between individuals, leading to
differences in susceptibility to autoimmune disease. We present single-cell RNA sequencing …

Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of
evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an …

Neutrophils are critical to innate immunity, including host defense against bacterial and
fungal infections. They achieve their host defense role by phagocytosing pathogens …

Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

Post-translational modifications of histones regulate all DNA-templated processes, including
replication, transcription and repair. These modifications function as platforms for the …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Together with core histones, which make up the nucleosome, the linker histone (H1) is one
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …

Neutrophil extracellular trap (NET) formation, first described in 2004 as a previously
unknown strategy of neutrophils to fight microbes, has attracted an increasing interest in the …