A new era of nanomedicines that involve nucleic acids/gene therapy has been opened after
two decades in 21st century and new types of more efficient drug delivery systems (DDS) …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

The brain is highly dependent on mitochondrial energy metabolism. As a result,
mitochondrial dysfunction is a central aspect of many adult-onset neurological diseases …

Epidemiologic studies have shown that in the aging society, a person dies from stroke every
3 minutes and 42 seconds, and vast numbers of people experience depression around the …

The kidney is a highly metabolic organ that requires substantial adenosine triphosphate for
the active transport required to maintain water and solute reabsorption. Aberrations in …

Neonatal hypoxic-ischemic (HI) injury is a severe complication often leading to neonatal
death and long-term neurobehavioral deficits in children. Currently, the only treatment option …

Uremic toxins (UTs) are mainly produced by protein metabolized by the intestinal microbiota
and converted in the liver or by mitochondria or other enzymes. The accumulation of UTs …

Significance: Hypoxic-ischemic events due to intrapartum complications represent the
second cause of neonatal mortality and initiate an acute brain disorder known as hypoxic …

Ischemic stroke is a devastating disease and one of the leading causes of mortality
worldwide. Overproduction of reactive oxygen species and inflammatory response …

Mitochondrial dysfunction in neurons has been implicated in hypoxia-ischemia-induced
brain injury. Although mesenchymal stem cell therapy has emerged as a novel treatment for …