Epigenetics of colorectal cancer: biomarker and therapeutic potential

G Jung, E Hernández-Illán, L Moreira… - Nature reviews …, 2020 - nature.com
Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …

miRNAs as cornerstones in colorectal cancer pathogenesis and resistance to therapy: A spotlight on signaling pathways interplay—A review

MA Elrebehy, S Al-Saeed, S Gamal, A El-Sayed… - International journal of …, 2022 - Elsevier
Colorectal cancer (CRC) is the world's third most prevalent cancer and the main cause of
cancer-related mortality. A lot of work has been put into improving CRC patients' clinical …

Novel diagnostic biomarkers in colorectal cancer

AL Zygulska, P Pierzchalski - International journal of molecular sciences, 2022 - mdpi.com
Colorectal cancer (CRC) is still a leading cause of cancer death worldwide. Less than half of
cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease …

Epigenetic alterations in colorectal cancer: emerging biomarkers

Y Okugawa, WM Grady, A Goel - Gastroenterology, 2015 - Elsevier
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …

Using circular RNA as a novel type of biomarker in the screening of gastric cancer

P Li, S Chen, H Chen, X Mo, T Li, Y Shao, B **ao… - Clinica chimica acta, 2015 - Elsevier
Abstract Background Circular RNAs (circRNAs), a class of endogenous RNAs, have
emerged as an enigmatic class of RNAs. Little is known about their value in the diagnosis of …

[HTML][HTML] Circulating biomarkers for early detection and clinical management of colorectal cancer

M Marcuello, V Vymetalkova, RPL Neves… - Molecular Aspects of …, 2019 - Elsevier
New non-invasive approaches that can complement and improve on current strategies for
colorectal cancer (CRC) screening and management are urgently needed. A growing …

Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1

Q He, A Ye, W Ye, X Liao, G Qin, Y Xu, Y Yin… - Cell death & …, 2021 - nature.com
Cancer-secreted exosomes are critical mediators of cancer-host crosstalk. In the present
study, we showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to …

[HTML][HTML] Colorectal cancer: from prevention to personalized medicine

G Binefa, F Rodríguez-Moranta, À Teule… - World journal of …, 2014 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is a very heterogeneous disease that is caused by the interaction
of genetic and environmental factors. CRC develops through a gradual accumulation of …

Colorectal cancer-derived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis

Y Shao, T Chen, XI Zheng, S Yang, K Xu… - …, 2018 - academic.oup.com
Liver metastases develop in more than half of the patients with colorectal cancer (CRC) and
are associated with a poor prognosis. The factors influencing liver metastasis of CRC are …

Advances in tests for colorectal cancer screening and diagnosis

SCH Chan, JQ Liang - Expert review of molecular diagnostics, 2022 - Taylor & Francis
Introduction Colorectal cancer (CRC) is the second leading cause of cancer-related deaths
globally. Nonetheless, with early detection of CRC or its precancerous lesions, mortality, and …