Messenger RNA regulation: to translate or to degrade

AB Shyu, MF Wilkinson, A Van Hoof - The EMBO journal, 2008 - embopress.org
Quality control of gene expression operates post‐transcriptionally at various levels in
eukaryotes. Once transcribed, mRNAs associate with a host of proteins throughout their …

Mechanism, factors, and physiological role of nonsense-mediated mRNA decay

T Fatscher, V Boehm, NH Gehring - Cellular and Molecular Life Sciences, 2015 - Springer
Nonsense-mediated mRNA decay (NMD) is a translation-dependent, multistep process that
degrades irregular or faulty messenger RNAs (mRNAs). NMD mainly targets mRNAs with a …

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

T Ohnishi, A Yamashita, I Kashima, T Schell… - Molecular cell, 2003 - cell.com
Eukaryotic mRNAs containing premature termination codons (PTCs) are degraded by a
process known as nonsense-mediated mRNA decay (NMD). NMD has been suggested to …

High-oleate peanut mutants result from a MITE insertion into the FAD2 gene

M Patel, S Jung, K Moore, G Powell… - Theoretical and Applied …, 2004 - Springer
A high-oleate trait in the cultivated peanut (Arachis hypogaea L.) was reported to rely on the
allelic composition of the two homeologous, microsomal oleoyl-PC desaturase genes …

[HTML][HTML] SMG‐5, required for C. elegans nonsense‐mediated mRNA decay, associates with SMG‐2 and protein phosphatase 2A

KR Anders, A Grimson, P Anderson - The EMBO journal, 2003 - embopress.org
mRNAs that contain premature stop codons are degraded selectively and rapidly in
eukaryotes, a phenomenon termed 'nonsense‐mediated mRNA decay'(NMD). We report …

Looking at mRNA decay pathways through the window of molecular evolution

MR Culbertson, PF Leeds - Current opinion in genetics & development, 2003 - Elsevier
In eukaryotes, mRNAs are monitored for errors in gene expression by RNA surveillance
where untranslatable mRNAs are selectively degraded by the nonsense-mediated mRNA …

SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans

A Grimson, S O'Connor, CL Newman… - Molecular and cellular …, 2004 - journals.asm.org
Eukaryotic messenger RNAs containing premature stop codons are selectively and rapidly
degraded, a phenomenon termed nonsense-mediated mRNA decay (NMD). Previous …

UPF3 suppresses aberrant spliced mRNA in Arabidopsis

K Hori, Y Watanabe - The Plant Journal, 2005 - Wiley Online Library
It has been reported that eukaryotic organisms have a nonsense‐mediated mRNA decay
(NMD) system to exclude aberrant mRNAs that produce truncated proteins. NMD is an RNA …

Translation repression by GLD-1 protects its mRNA targets from nonsense-mediated mRNA decay in C. elegans

MH Lee, T Schedl - Genes & development, 2004 - genesdev.cshlp.org
Previously, we identified multiple in vivo mRNA targets of the maxi-KH/STAR domain protein
GLD-1 by their ability to interact with GLD-1 in cytoplasmic extracts and, for all targets tested …

The evolution and diversity of the nonsense-mediated mRNA decay pathway

JPB Lloyd - F1000Research, 2018 - pmc.ncbi.nlm.nih.gov
Nonsense-mediated mRNA decay is a eukaryotic pathway that degrades transcripts with
premature termination codons (PTCs). In most eukaryotes, thousands of transcripts are …