Anticancer drugs continue to cause significant reductions in left ventricular ejection fraction
resulting in congestive heart failure. The best-known cardiotoxic agents are anthracyclines …

The HSP90 molecular chaperone is involved in the activation and cellular stabilization of a
range of 'client'proteins, of which oncogenic protein kinases and nuclear steroid hormone …

Hsp90 is an essential chaperone that guards proteome integrity and amounts to 2% of
cellular protein. We now find that Hsp90 also has the ability to directly interact with and …

Simple Summary Cancer is largely caused by genetic alterations such as mutations in a
group of genes known as cancer driver genes. Many of the key advances in cancer …

ABSTRACT Echinocandins (caspofungin, micafungin, anidulafungin), targeting β-1, 3-
glucan synthesis of the cell wall, represent one of the three currently available antifungal …

T-cell-based immunotherapies are promising treatments for cancer patients. Although
durable responses can be achieved in some patients, many patients fail to respond to these …

Oncogene stability and homeostasis mediated by the HSP90 chaperone is a crucial
protection trait of cancer cells. Therefore, HSP90 represents an attractive therapeutic target …

Activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) is driven by aberrant
activation of the B-cell receptor (BCR) and the TLR/MyD88 signaling pathways. The heat …

Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-
isomerase domain. High molecular weight immunophilins are characterized by the …

In this Opinion article, we aim to address how cells adapt to stress and the repercussions
chronic stress has on cellular function. We consider acute and chronic stress-induced …