Autoimmune diseases are a diverse set of conditions defined by organ damage due to
abnormal innate and acquired immune system responses. The pathophysiology of …

Summary G-quadruplexes (G4s) are stable, noncanonical structures formed in guanine (G)-
rich sequences of DNA/RNA. G4 structures are reported to play a regulatory role in various …

Targeted protein degradation (TPD) represented by proteolysis targeting chimeras
(PROTACs) marks a significant stride in drug discovery. A plethora of innovative …

ABSTRACT RNA helicases are integral in RNA metabolism, performing important roles in
cellular homeostasis and stress responses. In particular, the DExD/H-box (DDX) helicase …

Translation is one of the most energy-intensive processes in a cell and, accordingly, is tightly
regulated. Genome-wide methods to measure translation and the translatome and to study …

RNA structure constitutes a new layer of gene regulatory mechanisms. RNA binding proteins
can modulate RNA secondary structures, thus participating in post-transcriptional regulation …

Nucleic acid binding proteins regulate transcription, splicing, RNA stability, RNA localization,
and translation, together tailoring gene expression in response to stimuli. Upon discovery …

RNA G-quadruplexes (rG4s) are non-canonical secondary nucleic acid structures found in
the transcriptome. They play crucial roles in gene regulation by interacting with G4-binding …

Werner syndrome of premature aging is caused by mutations in the WRN RECQ
helicase/exonuclease, which functions in DNA replication, repair, transcription, and telomere …

Abstract 3′ untranslated regions (3′ UTRs) of mRNAs have many functions, including
mRNA processing and transport, translational regulation, and mRNA degradation and …