Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

Surface curvature both emerges from, and influences the behavior of, living objects at length
scales ranging from cell membranes to single cells to tissues and organs. The relevance of …

Current techniques for visualizing and quantifying cellular forces have limitations in live cell
imaging, throughput, and multi-scale analysis, which impede progress in cell force research …

Organoids, intricate three-dimensional tissue assemblies derived from either pluripotent or
adult stem cells cultured under laboratory conditions, emerge as a captivating model and …

From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …

During embryogenesis tissue layers undergo morphogenetic flow rearranging and folding
into specific shapes. While developmental biology has identified key genes and local …

A primary challenge in tissue engineering is to recapitulate both the structural and functional
features of whole tissues and organs. In vivo, patterning of the body plan and constituent …

Inflammatory bowel disease (IBD), a chronic inflammatory disease of the gastrointestinal
tract, is characterized by abdominal pain, diarrhea, and bloody stools, posing a serious …

Physical forces are essential to biological function, but their impact at the tissue level is not
fully understood. The gut is under continuous mechanical stress because of peristalsis. To …

The small intestine displays marked anatomical and functional plasticity that includes
adaptive alterations in adult gut morphology, enteroendocrine cell profile and their hormone …