Senescence compromises the essential role that the endothelium plays in maintaining
vascular homeostasis, so promoting endothelial dysfunction and the development of age …

Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner
cellular lining of arteries, veins and capillaries and therefore is in direct contact with the …

Tobacco smoking is a leading cause of non-communicable disease globally and is a major
risk factor for cardiovascular disease (CVD) and lung disease. Importantly, recent data by …

Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …

Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

The kidney harbours different types of endothelia, each with specific structural and functional
characteristics. The glomerular endothelium, which is highly fenestrated and covered by a …

Endothelial cells (ECs) are sentinels of cardiovascular health. Their function is reduced by
the presence of cardiovascular risk factors, and is regained once pathological stimuli are …

Body mass index (BMI) and dyslipidemia are indicators of human health and are often
associated with high blood pressure. In this study, we explored the relationship between BMI …

Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …