Since first described in the early 1900s, Alzheimer's disease (AD) has risen exponentially in
prevalence and concern. Research still drives to understand the etiology and pathogenesis …

Epileptic activity is frequently associated with Alzheimer's disease; this association has
therapeutic implications, because epileptic activity can occur at early disease stages and …

The rapid elimination of dying neurons and nonfunctional synapses in the brain is carried
out by microglia, the resident myeloid cells of the brain. Here we show that microglia …

Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is
associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that …

Seizures can occur spontaneously and in a recurrent manner, which defines epilepsy; or
they can be induced in a normal brain under a variety of conditions in most neuronal …

2. King MA, Newton MR, Jackson GD, Fitt GJ, Mitchell LA, Silvapulle MJ, et al. Epileptology
of the first-seizure presentation: a clinical, electroencephalographic, and magnetic …

In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …

In this review, we discuss the significance of the synaptic excitation/inhibition (E/I) balance in
the context of homeostatic plasticity, whose primary goal is thought to maintain neuronal …

Background: Epilepsy is a chronic disorder affecting all ages but with a peak in the elderly.
The association of epilepsy with age can be explained by the predominance of brain …

A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and
epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in …