Phosphoinositides are an important class of anionic, low abundance signaling lipids
distributed throughout intracellular membranes. The plasma membrane contains three …

Egypt is the third most densely inhabited African country. Due to the economic burden and
healthcare costs of overpopulation, genomic and genetic testing is a huge challenge …

Genetic defects in myelin formation and maintenance cause leukodystrophies, a group of
white matter diseases whose mechanistic underpinnings are poorly understood …

Active membrane remodeling during myelination relies on phospholipid synthesis and
membrane polarization, both of which are known to depend on inositol phospholipids. Here …

In recent years, the concept of hypomyelinating disorders has been proposed as a group of
disorders with varying systemic manifestations that are identified by MR findings of absence …

Objective: To identify the genetic cause of a familial form of late-onset action myoclonus in 2
unrelated patients. Both probands had 2 siblings displaying a similar disorder. Extensive …

Phosphatidylinositol 4-kinase IIIα (PI4KIIIα) is the major enzyme responsible for generating
phosphatidylinositol (4)-phosphate [PI (4) P] at the plasma membrane. This lipid kinase …

Alternative splicing of pre-mRNAs significantly contributes to the complexity of gene
expression in higher organisms, but the regulation of the splice site selection remains …

Cytokinesis marks the culmination of cell division when the cytoplasm undergoes division to
yield two daughter cells. This intricate process encompasses various biological phenomena …

Abstract A interleucina-6 (IL-6) é uma citocina multifuncional com propriedades
pleiotrópicas bem definidas derivada de um gene polimórfico. O gene IL6 está localizado no …