Abdominal wall blocks rely on the spread of local anesthetic within musculofascial planes to
anesthetize multiple small nerves or plexuses, rather than targeting specific nerve structures …

Visceral pain is a global term used to describe pain originating from the internal organs of
the body, which affects a significant proportion of the population and is a common feature of …

The third edition of this monograph continues to have the goal of providing an overview of
current thought about the spinal cord mechanisms that are responsible for sensory …

Abdominal pain is common in the general population and, in patients with irritable bowel
syndrome, is attributed to visceral hypersensitivity. We found that oral administration of …

Women and men are suggested to have differences in vulnerability to neuropsychiatric
disorders, including major depressive disorder (MDD), generalized anxiety disorder (GAD) …

Pain is ultimately a perceptual phenomenon. It is built from information gathered by
specialized pain receptors in tissue, modified by spinal and supraspinal mechanisms, and …

Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

Understanding the plasticity of pain and analgesia exhibited in different pain states may
improve therapies for the two major types of pain, neuropathic and inflammatory pain, in …

Pain referral and spread in headache patients may be attributed to a sensitization of central
nociceptive neurons with an increased excitability to afferent input. We investigated if …

Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient
receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved …