Fear generalization and anxiety: behavioral and neural mechanisms
Fear can be an adaptive emotion that helps defend against potential danger. Classical
conditioning models elegantly describe how animals learn which stimuli in the environment …
conditioning models elegantly describe how animals learn which stimuli in the environment …
Fear generalization in humans: systematic review and implications for anxiety disorder research
Fear generalization, in which conditioned fear responses generalize or spread to related
stimuli, is a defining feature of anxiety disorders. The behavioral consequences of …
stimuli, is a defining feature of anxiety disorders. The behavioral consequences of …
Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies
Classical Pavlovian fear conditioning remains the most widely employed experimental
model of fear and anxiety, and continues to inform contemporary pathophysiological …
model of fear and anxiety, and continues to inform contemporary pathophysiological …
Context processing and the neurobiology of post-traumatic stress disorder
I Liberzon, JL Abelson - Neuron, 2016 - cell.com
Progress in clinical and affective neuroscience is redefining psychiatric illness as
symptomatic expression of cellular/molecular dysfunctions in specific brain circuits. Post …
symptomatic expression of cellular/molecular dysfunctions in specific brain circuits. Post …
The role of associative fear and avoidance learning in anxiety disorders: Gaps and directions for future research
Anxiety disorders are the most common mental disorders and are often chronic and
disabling. Although exposure-based treatments are effective, a substantial number of …
disabling. Although exposure-based treatments are effective, a substantial number of …
Post-traumatic stress symptoms in COVID-19 survivors: a self-report and brain imaging follow-up study
Previous coronavirus pandemics were associated elevated post-traumatic stress symptoms
(PTSS), but the self-report and neurological basis of PTSS in patients who survived …
(PTSS), but the self-report and neurological basis of PTSS in patients who survived …
The neurobiology of fear generalization
The generalization of fear memories is an adaptive neurobiological process that promotes
survival in complex and dynamic environments. When confronted with a potential threat, an …
survival in complex and dynamic environments. When confronted with a potential threat, an …
Neural substrates of overgeneralized conditioned fear in PTSD
Objective: Heightened generalization of fear from an aversively reinforced conditioned
stimulus (CS+, a conditioned danger cue) to resembling stimuli is widely accepted as a …
stimulus (CS+, a conditioned danger cue) to resembling stimuli is widely accepted as a …
Extending the amygdala in theories of threat processing
The central extended amygdala is an evolutionarily conserved set of interconnected brain
regions that play an important role in threat processing to promote survival. Two core …
regions that play an important role in threat processing to promote survival. Two core …
A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder
Posttraumatic stress disorder (PTSD) is a debilitating condition associated with mild to
moderate cognitive impairment and with a prevalence rate of up to 22% in veterans. This …
moderate cognitive impairment and with a prevalence rate of up to 22% in veterans. This …