Beyond horizontal gene transfer: the role of plasmids in bacterial evolution

J Rodríguez-Beltrán, J DelaFuente… - Nature Reviews …, 2021 - nature.com
Plasmids have a key role in bacterial ecology and evolution because they mobilize
accessory genes by horizontal gene transfer. However, recent studies have revealed that …

Antibiotic-resistance genes in waste water

A Karkman, TT Do, F Walsh, MPJ Virta - Trends in microbiology, 2018 - cell.com
Waste water and waste water treatment plants can act as reservoirs and environmental
suppliers of antibiotic resistance. They have also been proposed to be hotspots for …

Discovery of potential multi-target-directed ligands by targeting host-specific SARS-CoV-2 structurally conserved main protease

RS Joshi, SS Jagdale, SB Bansode… - Journal of …, 2021 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in
the current COVID-19 pandemic. Worldwide this disease has infected over 2.5 million …

Long-term field application of sewage sludge increases the abundance of antibiotic resistance genes in soil

Q Chen, X An, H Li, J Su, Y Ma, YG Zhu - Environment international, 2016 - Elsevier
Sewage sludge and manure are common soil amendments in crop production; however,
their impact on the abundance and diversity of the antibiotic resistome in soil remains …

Conjugative plasmids interact with insertion sequences to shape the horizontal transfer of antimicrobial resistance genes

Y Che, Y Yang, X Xu, K Břinda… - Proceedings of the …, 2021 - National Acad Sciences
It is well established that plasmids play an important role in the dissemination of
antimicrobial resistance (AMR) genes; however, little is known about the role of the …

Antibiotic resistance in Pseudomonas aeruginosa–Mechanisms, epidemiology and evolution

J Botelho, F Grosso, L Peixe - Drug resistance updates, 2019 - Elsevier
Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

Mobility of plasmids

C Smillie, MP Garcillán-Barcia… - Microbiology and …, 2010 - Am Soc Microbiol
Plasmids are key vectors of horizontal gene transfer and essential genetic engineering tools.
They code for genes involved in many aspects of microbial biology, including detoxication …

Comparison of antibiotic-resistant bacteria and antibiotic resistance genes abundance in hospital and community wastewater: A systematic review

N Hassoun-Kheir, Y Stabholz, JU Kreft… - Science of the Total …, 2020 - Elsevier
Antibiotic-resistant bacteria (ARB) and antibiotic-resistance genes (ARGs) are constantly
shed into the aquatic environment, with hospital wastewater potentially acting as an …

The ecology and evolution of pangenomes

MA Brockhurst, E Harrison, JPJ Hall, T Richards… - Current Biology, 2019 - cell.com
Since the first genome-scale comparisons, it has been evident that the genomes of many
species are unbound by strict vertical descent: Large differences in gene content can occur …

Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gram-negative pathogens

HW Stokes, MR Gillings - FEMS microbiology reviews, 2011 - academic.oup.com
Antibiotics were one of the great discoveries of the 20th century. However, resistance
appeared even in the earliest years of the antibiotic era. Antibiotic resistance continues to …