Microglia are the only resident innate immune cells derived from the mesoderm in the nerve
tissue. They play a role in the development and maturation of the central nervous system …

Microglia are specialized immune cells unique to the central nervous system (CNS).
Microglia have a highly plastic morphology that changes rapidly in response to injury or …

Identifying secreted mediators that drive the cognitive benefits of exercise holds great
promise for the treatment of cognitive decline in ageing or Alzheimer's disease (AD). Here …

Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark of
several chronic neurological diseases, including multiple sclerosis. Distinct metabolic and …

Background Neuroinflammation is one of the most important processes in secondary injury
after traumatic brain injury (TBI). Triggering receptor expressed on myeloid cells 2 (TREM2) …

The cell‐to‐cell transfer of α‐synuclein (α‐Syn) greatly contributes to Parkinson's disease
(PD) pathogenesis and underlies the spread of α‐Syn pathology. During this process …

The mechanistic target of rapamycin (mTOR) signaling pathway plays a major role in key
cellular processes including metabolism and differentiation; however, the role of mTOR in …

Human genetics implicate defective myeloid responses in the development of late-onset
Alzheimer disease. A decline in peripheral and brain myeloid metabolism, triggering …

Microglia are the principal phagocytes that clear cell debris in the central nervous system
(CNS). This raises the question, which cells remove cell debris when microglial phagocytic …

Hematopoietic cell transplantation after myeloablative conditioning has been used to treat
various genetic metabolic syndromes but is largely ineffective in diseases affecting the brain …