Tumour formation involves the co-evolution of neoplastic cells together with extracellular
matrix, tumour vasculature and immune cells. Successful outgrowth of tumours and eventual …

There is a growing recognition that gliomas are complex tumors composed of neoplastic and
non-neoplastic cells, which each individually contribute to cancer formation, progression …

Neurofibromatosis type 1 is a complex autosomal dominant disorder caused by germline
mutations in the NF1 tumour suppressor gene. Nearly all individuals with neurofibromatosis …

Cancer is a complex collection of distinct genetic diseases united by common hallmarks.
Here, we expand upon the classic hallmarks to include the stress phenotypes of …

Background Effective medical therapies are lacking for the treatment of neurofibromatosis
type 1–related plexiform neurofibromas, which are characterized by elevated RAS–mitogen …

Solid tumors are not simply clones of cancer cells. Instead, they are abnormal organs
composed of multiple cell types and extracellular matrix. Some aspects of tumor …

Mesenchymal cells contribute to the 'stroma'of most normal and malignant tissues, with
specific mesenchymal cells participating in the regulatory niches of stem cells. By examining …

Neurofibromatosis type 1 is a relatively common inherited disorder. Patients have a high
predisposition to develop both benign and malignant tumours. Although many …

Abstract Neurofibromatosis type 1 (NF1) is a common genetic disorder that predisposes
affected individuals to tumours. The NF1 gene encodes a RAS GTPase-activating protein …

Neuronal activity is emerging as a driver of central and peripheral nervous system cancers.
Here, we examined neuronal physiology in mouse models of the tumor predisposition …