The therapeutic use of many pharmaceuticals, including small molecules and biological
therapies, has been associated with the onset of psychiatric and psychological adverse …

Promising drug development efforts may frequently fail due to unintended adverse reactions.
Several methods have been developed to analyze such data, aiming to improve …

Aims The objective of this study is to compare the adverse events (AEs) associated with
pralsetinib and selpercatinib. Methods To evaluate the imbalance of AEs linked to …

The NF-E2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway is a potential
therapeutic target for central nervous system diseases. This review emphasizes the role of …

The pyrilamine-sensitive proton-coupled organic cation (H+/OC) antiporter system facilitates
the active net uptake of several marketed organic cationic drugs across the blood-brain …

Several pyrazoloquinolinone (PQ) ligands were recently discovered as functionally selective
positive modulators at the PQ site of α6‐containing GABAA receptors. PQs are also neutral …

Iron oxide nanoparticles (IONPs) have useful properties, such as strong magnetism and
compatibility with living organisms which is preferable for medical applications such as drug …

Abstract Human induced Pluripotent Stem Cell (hiPSC) derived neural cells offer great
potential for modelling neurological diseases and toxicities and have found application in …

GABAA receptors, members of the pentameric ligand-gated ion channel superfamily, are
widely expressed in the central nervous system and mediate a broad range of pharmaco …

Introduction Medications which target benzodiazepine (BZD) binding sites of GABAA
receptors (GABAARs) have been in widespread use since the nineteen-sixties. They carry …