Aspergillus fumigatus and Aspergillosis in 2019

JP Latgé, G Chamilos - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

Development of lung tissue models and their applications

N Petpiroon, W Netkueakul, K Sukrak, C Wang, Y Liang… - Life Sciences, 2023 - Elsevier
The lungs are important organs that play a critical role in the development of specific
diseases, as well as responding to the effects of drugs, chemicals, and environmental …

Inhaled antifungal therapy: benefits, challenges, and clinical applications

K Ito - Expert Opinion on Drug Delivery, 2022 - Taylor & Francis
Introduction Disease due to pulmonary infection with Aspergillus, and other emerging
opportunistic fungi remains a significant unmet need. Existing antifungal medicines are …

Mass spectrometry-based proteomics of fungal pathogenesis, host–fungal interactions, and antifungal development

B Ball, A Bermas, D Carruthers-Lay… - Journal of Fungi, 2019 - mdpi.com
The prevalence of fungal diseases is increasing on a global scale, ranging from acute to
systemic infections caused by commensal or pathogenic microorganisms, often associated …

Human airway epithelium responses to invasive fungal infections: A critical partner in innate immunity

AJ Crossen, RA Ward, JL Reedy, MV Surve, BS Klein… - Journal of Fungi, 2022 - mdpi.com
The lung epithelial lining serves as the primary barrier to inhaled environmental toxins,
allergens, and invading pathogens. Pulmonary fungal infections are devastating and carry …

Expression of immune response genes in human corneal epithelial cells interacting with Aspergillus flavus conidia

D Arunachalam, SM Ramanathan, A Menon, L Madhav… - BMC genomics, 2022 - Springer
Background Aspergillus flavus, one of the causative agents of human fungal keratitis, can be
phagocytosed by human corneal epithelial (HCE) cells and the conidia containing …

Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus

J Bigot, L Guillot, J Guitard, M Ruffin, H Corvol… - Frontiers in …, 2020 - frontiersin.org
Aspergillus fumigatus is an environmental filamentous fungus that can be pathogenic for
humans, wherein it is responsible for a large variety of clinical forms ranging from allergic …

Characterization and pro‐inflammatory potential of indoor mold particles

JA Holme, E Øya, AKJ Afanou, J Øvrevik, W Eduard - Indoor Air, 2020 - Wiley Online Library
A number of epidemiological studies find an association between indoor air dampness and
respiratory health effects. This is often suggested to be linked to enhanced mold growth …

[HTML][HTML] Invasive aspergillosis-on-chip: A quantitative treatment study of human Aspergillus fumigatus infection

TNM Hoang, Z Cseresnyés, S Hartung, M Blickensdorf… - Biomaterials, 2022 - Elsevier
Invasive pulmonary aspergillosis is associated with a high mortality rate and poses a direct
threat to immunocompromised patients. Here, we present the invasive aspergillosis-on-chip …

In vitro infection models to study fungal–host interactions

A Last, M Maurer, A S. Mosig… - FEMS Microbiology …, 2021 - academic.oup.com
Fungal infections (mycoses) affect over a billion people per year. Approximately, two million
of these infections are life-threatening, especially for patients with a compromised immune …