Multi-drug resistance profile of PR20 HIV-1 protease is attributed to distorted conformational and drug binding landscape: molecular dynamics insights

S Chetty, S Bhakat, AJM Martin… - Journal of Biomolecular …, 2016 - Taylor & Francis
The PR20 HIV-1 protease, a variant with 20 mutations, exhibits high levels of multi-drug
resistance; however, to date, there has been no report detailing the impact of these 20 …

Focus on new antiviral drugs for AIDS and smallpox treatments.

JK Borchardt - Drug News & Perspectives, 2006 - europepmc.org
More than 400 papers on medicinal chemistry were presented at the 231st National Meeting
of the American Chemical Society in Atlanta, Georgia, USA, March 26-30, 2006. A major …