Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …

Despite development of novel agents targeting oncogenic pathways, matching targeted
therapies to the genetic status of individual tumors is proving to be a daunting task for …

Over the past two decades, our understanding of phospoinositide 3-kinases (PI3Ks) has
progressed from the identification of an enzymatic activity associated with growth factors …

The importance of PTEN in cellular function is underscored by the frequency of its
deregulation in cancer. PTEN tumor-suppressor activity depends largely on its lipid …

The phosphatidylinositol 3-kinase (PI3K) signaling axis impacts on cancer cell growth,
survival, motility, and metabolism. This pathway is activated by several different mechanisms …

Phosphatidylinositol (PtdIns) 3-kinase is an enzyme implicated in growth factor signal
transduction by associating with receptor and nonreceptor tyrosine kinases, including the …

▪ Abstract Src family protein tyrosine kinases are activated following engagement of many
different classes of cellular receptors and participate in signaling pathways that control a …

Almost thirty years ago, PI3K was discovered as a lipid kinase associated with certain
oncoproteins. The first decade of research on PI3K saw the identification, purification and …

Cells prepare for S phase during the G1 phase of the cell cycle. Cell biological methods
have provided knowledge of cycle kinetics and of substages of G1 that are determined by …

SINCE the discovery of insulin nearly 70 years ago, there has been no problem more
fundamental to diabetes research than understanding how insulin works at the cellular level …