The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Psychiatric disorders are now responsible for the largest proportion of the global burden of
disease, and even more challenges have been seen during the COVID-19 pandemic …

Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …

Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …

Introduction Growing demand for mental health services, coupled with funding and resource
limitations, creates an opportunity for novel technological solutions including artificial …

Culture is a complex topic involving a comprehensive representation of human institutions,
social customs, norms, and lifestyles. Over the past half-century, the methods of cultural …

Despite 50+ years of drug discovery, current antipsychotics have limited efficacy against
negative and cognitive symptoms of schizophrenia, and are ineffective—with the exception …

Functional neuroimaging emerged with great promise and has provided fundamental
insights into the neurobiology of schizophrenia. However, it has faced challenges and …

Highlights•Resting-state fMRI biomarkers in psychiatry often lack disorder specificity.•
Transdiagnostic study designs allow direct assessment of biomarker specificity.•p-factor …