Imidazole ring is an important five‐membered aromatic heterocycle widely present in natural
products and synthetic molecules. The unique structural feature of imidazole ring with …

Chroman-4-one scaffold is a privileged structure in heterocyclic chemistry and drug
discovery. Also, chroman-4-ones are important intermediates and interesting building blocks …

Azole compounds are an important class of nitrogen heterocycles with electron-rich
property. This special structure endows azole-based derivatives easily bind with the …

The azole antifungal drugs are an important class of chemotherapeutic agents with broad-
spectrum of activity against yeasts and filamentous fungi, act in the ergosterol biosynthetic …

Imidazoles are one of the most promising and vigorously pursued areas of contemporary
antifungal chemotherapy depicting broad spectrum and potent activity. They have relatively …

Leishmaniasis is a protozoan infectious disease widely distributed all around the world. First
line drugs including antimoniales are insufficient due to resistance in endemic areas and …

A series of new triazole alcohol antifungals were designed by replacing one of the triazolyl
moiety from fluconazole with a distinct 4-amino-3-mercapto-1, 2, 4-triazole motif, which is …

Abstract A series of novel 3-(1, 2, 4-triazol-1-yl) flavanones were synthesized based on the N-
phenethylazole pharmacophore of azole antifungals. The results of antifungal assay …

Abstract A series of furo [3, 2‐g] chromone derivatives were synthesized via the reaction of
furochromone carbaldehyde 1 with amines 3a‐d and thioglycolic acid to give …

Antimicrobial resistance is a major global threat. In an attempt to discover new compounds
with improved efficiency and to overcome drug resistance, a library of 3960 compounds was …