Macrophages are cells of the innate immunity constituting the mononuclear phagocyte
system and endowed with remarkable different roles essential for defense mechanisms …

Novel treatment approaches are needed to overcome innate and acquired mechanisms of
resistance to current anticancer therapies in cancer cells and the tumour immune …

Onco-fetal reprogramming of the tumor ecosystem induces fetal developmental signatures in
the tumor microenvironment, leading to immunosuppressive features. Here, we employed …

Mononuclear phagocyte plasticity includes the expression of functions related to the
resolution of inflammation, tissue repair and remodelling, particularly when these cells are …

The TYRO3, AXL (also known as UFO) and MERTK (TAM) family of receptor tyrosine
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …

Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate
recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive …

Mer tyrosine kinase (MerTK) is a major macrophage apoptotic cell (AC) receptor. Its
functional impairment promotes autoimmunity and atherosclerosis, whereas overexpression …

The TAM receptor tyrosine kinases (RTKs)—T YRO3, A XL, and M ERTK—together with their
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …

Smouldering inflammation is a component of the tumor microenvironment and represents
the 7th hallmark of cancer. Tumor-associated macrophages (TAM) have served as a …

Intratumor heterogeneity is a key factor contributing to therapeutic failure and, hence, cancer
lethality. Heterogeneous tumors show partial therapy responses, allowing for the emergence …