Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Cisplatin, carboplatin, nedaplatin, and oxaliplatin are widely used in contemporary
oncology; however, their ototoxic and neurotoxic side effects are quite different as discussed …

Cancer stem cells (CSCs) presumably contribute to tumor progression and drug resistance,
yet their definitive features have remained elusive. Here, simultaneous measurement of …

Tinnitus, the perception of sound in the absence of an auditory stimulus, is perceived by
about 1 in 10 adults, and for at least 1 in 100, tinnitus severely affects their quality of life …

Background: The association between antihypertensive medications and survival in cancer
patients remains unclear. Objectives: To explore the association between classes of …

Physiological roles of Cl−, a major anion in the body, are not well known compared with
those of cations. This review article introduces:(1) roles of Cl− in bodily and cellular …

Glioblastoma is the most common and lethal primary intracranial tumor. As the key regulator
of tumor cell volume, sodium‐potassium‐chloride cotransporter 1 (NKCC1) expression …

Subjective tinnitus, the phantom ringing or buzzing sensation that occurs in the absence of
sound, affects 12–14% of adults; in some cases the tinnitus is so severe or disabling that …

The aim of the present study is to investigate whether the chloride affects cell growth and cell-
cycle progression of cancer cells. In human gastric cancer MKN28 cells, the culture in the …

Digestive system neoplasms are the leading causes of cancer-related death all over the
world. Solute carrier (SLC) superfamily is composed of a series of transporters that are …