[HTML][HTML] Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes
M Deponte - Biochimica et Biophysica Acta (BBA)-General Subjects, 2013 - Elsevier
BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …
challenges encountered by all life forms. In the course of evolution, nature optimized …
Lest we forget you—methylene blue…
RH Schirmer, H Adler, M Pickhardt, E Mandelkow - Neurobiology of aging, 2011 - Elsevier
Methylene blue (MB), the first synthetic drug, has a 120-year-long history of diverse
applications, both in medical treatments and as a staining reagent. In recent years there was …
applications, both in medical treatments and as a staining reagent. In recent years there was …
Cellular and molecular actions of methylene blue in the nervous system
Methylene Blue (MB), following its introduction to biology in the 19th century by Ehrlich, has
found uses in various areas of medicine and biology. At present, MB is the first line of …
found uses in various areas of medicine and biology. At present, MB is the first line of …
An overview on the clinical development of tau-based therapeutics
M Medina - International journal of molecular sciences, 2018 - mdpi.com
Tauopathies such as Alzheimer's disease (AD), frontotemporal lobar degeneration, or
progressive supranuclear palsy constitute a group of brain disorders defined by …
progressive supranuclear palsy constitute a group of brain disorders defined by …
Methylene blue and Alzheimer's disease
The relationship between methylene blue (MB) and Alzheimer's disease (AD) has recently
attracted increasing scientific attention since it has been suggested that MB may slow down …
attracted increasing scientific attention since it has been suggested that MB may slow down …
Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs
MJ Delves, A Ruecker, U Straschil… - Antimicrobial agents …, 2013 - Am Soc Microbiol
It is the mature gametocytes of Plasmodium that are solely responsible for parasite
transmission from the mammalian host to the mosquito. They are therefore a logical target …
transmission from the mammalian host to the mosquito. They are therefore a logical target …
High-throughput assay and discovery of small molecules that interrupt malaria transmission
Preventing transmission is an important element of malaria control. However, most of the
current available methods to assay for malaria transmission blocking are relatively low …
current available methods to assay for malaria transmission blocking are relatively low …
Use of biodegradable, chitosan-based nanoparticles in the treatment of Alzheimer's disease
E Manek, F Darvas, GA Petroianu - Molecules, 2020 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects more than
24 million people worldwide and represents an immense medical, social and economic …
24 million people worldwide and represents an immense medical, social and economic …
Efficacy and safety of methylene blue in the treatment of malaria: a systematic review
G Lu, M Nagbanshi, N Goldau, M Mendes Jorge… - BMC medicine, 2018 - Springer
Background Methylene blue (MB) was the first synthetic antimalarial to be discovered and
was used during the late 19th and early 20th centuries against all types of malaria. MB has …
was used during the late 19th and early 20th centuries against all types of malaria. MB has …
Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau
K Hochgräfe, A Sydow, D Matenia, D Cadinu… - Acta neuropathologica …, 2015 - Springer
Introduction Neurofibrillary tangles (NFT) composed of Tau are hallmarks of
neurodegeneration in Alzheimer disease. Transgenic mice expressing full-length pro …
neurodegeneration in Alzheimer disease. Transgenic mice expressing full-length pro …