Tyrosine kinases, enzymes that catalyze the transfer of phosphate from ATP to tyrosine
residues in polypeptides, are ubiquitous, numerous, and of considerable clinical interest …

Primary eosinophilic gastrointestinal disorders are defined as disorders that selectively
affect the gastrointestinal tract with eosinophil-rich inflammation in the absence of known …

Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of diverse inflammatory responses, as well as modulators of innate and adaptive immunity …

Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important
functions in the regulation of growth and survival of certain cell types during embryonal …

The human eosinophil has long been thought to favorably influence innate mucosal
immunity but at times has also been incriminated in disease pathophysiology. Research into …

Disease overview The eosinophilias encompass a broad range of non‐hematologic
(secondary or reactive) and hematologic (primary or clonal) disorders with potential for end …

BACKGROUND: Hypereosinophilic syndrome (HES) is a heterogeneous group of rare
disorders defined by persistent blood eosinophilia≥ 1.5× 109/L, absence of a secondary …

Eosinophils have long been known to infiltrate tumors, and in most cases, this is associated
with an improved prognosis. However, the reasons behind this infiltration and the …

Molecular diagnostics has generated substantial dividends in dissecting the genetic basis of
myeloid neoplasms with eosinophilia. The family of diseases generated by dysregulated …

Overview Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast
cells (MCs) in extra‐cutaneous organs. Diagnosis The major criterion is presence of …