Sequence analysis is the primary and simplest approach to discover structural, functional
and evolutionary details of related proteins. All the alignment based approaches of …

Advancements in genome sequencing have expanded the scope of investigating mutations
in proteins across different diseases. Amino acid mutations in a protein alter its structure …

Moonlighting proteins, known for their ability to perform multiple, often unrelated functions
within a single polypeptide chain, challenge the traditional “one gene, one protein, one …

The origin of the genetic code and the rooting of the tree of life (ToL) are two of the most
challenging problems in the study of life's early evolution. Although both have been the …

Repetitive low complexity sequences, mostly assumed to have no function, are common in
proteins that are exported by the malaria parasite into its host erythrocyte. We identify a …

Glycosyltransferases are one of the largest and most diverse enzyme groups in Nature. They
catalyse the synthesis of glycosidic linkages by the transfer of a sugar residue from a donor …

The genome of the malarial parasite Plasmodium falciparum is extremely AT rich. This bias
toward a low GC content is a characteristic of several, but not all, species within the genus …

Background Temperature adaptation of biological molecules is fundamental in evolutionary
studies but remains unsolved. Fishes living in cold water are adapted to low temperatures …

Integrated platforms for storage, management, analysis and sharing of large quantities of
omics data have become fundamental to comparative genomics. CoGe (https …

Background Subtelomeric RIFIN genes constitute the most abundant multigene family in
Plasmodium falciparum. RIFIN products are targets for the human immune response and …