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Deciphering Specificity Determinants for FR900359‐Derived Gqα Inhibitors Based on Computational and Structure–Activity Studies
R Reher, T Kühl, S Annala, T Benkel… - …, 2018 - Wiley Online Library
Direct targeting of intracellular Gα subunits of G protein‐coupled receptors by chemical tools
is a challenging task in current pharmacological studies and in the development of novel …
is a challenging task in current pharmacological studies and in the development of novel …
A Specialized Dehydrogenase Provides l‐Phenyllactate for FR900359 Biosynthesis
S Klöppel, R Richarz, DA Wirtz, N Vasenda… - …, 2022 - Wiley Online Library
Abstract d‐Phenyllactate (PLA) is a component of the selective Gq protein inhibitor and
nonribosomal cyclic depsipeptide FR900359 (FR). Here we report a detailed biochemical …
nonribosomal cyclic depsipeptide FR900359 (FR). Here we report a detailed biochemical …