Merkel cell carcinoma

JC Becker, A Stang, JA DeCaprio, L Cerroni… - Nature reviews Disease …, 2017 - nature.com
Merkel cell carcinoma (MCC) is a rare but highly aggressive skin cancer with
neuroendocrine features. MCC pathogenesis is associated with either the presence of …

[HTML][HTML] Merkel cell carcinoma: epidemiology, prognosis, therapy and unmet medical needs

D Schadendorf, C Lebbé, A Zur Hausen… - European journal of …, 2017 - Elsevier
Merkel cell carcinoma (MCC) is a rare skin cancer that is associated with Merkel cell
polyomavirus infection in most cases. Incidence rates of MCC have increased in past …

Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial

HL Kaufman, J Russell, O Hamid, S Bhatia… - The lancet …, 2016 - thelancet.com
Background Merkel cell carcinoma is a rare, aggressive skin cancer with poor prognosis in
patients with advanced disease. Current standard care uses various cytotoxic chemotherapy …

The biology and treatment of Merkel cell carcinoma: current understanding and research priorities

PW Harms, KL Harms, PS Moore… - Nature reviews Clinical …, 2018 - nature.com
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer associated with
advanced age and immunosuppression. Over the past decade, an association has been …

The distinctive mutational spectra of polyomavirus-negative Merkel cell carcinoma

PW Harms, P Vats, ME Verhaegen, DR Robinson… - Cancer research, 2015 - AACR
Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine
tumor. Merkel cell polyomavirus (MCPyV) may contribute to tumorigenesis in a subset of …

Viral infections

JC Sterling - Rook's Textbook of Dermatology, Ninth Edition, 2016 - Wiley Online Library
Skin disease due to viruses may be a primary infection of the epidermis or may arise
secondary to systemic infection. Depending on the virus, the effects may be necrotic damage …

PD-L1 expression in the Merkel cell carcinoma microenvironment: association with inflammation, Merkel cell polyomavirus, and overall survival

EJ Lipson, JG Vincent, M Loyo, LT Kagohara… - Cancer immunology …, 2013 - AACR
Merkel cell carcinoma (MCC) is a lethal, virus-associated cancer that lacks effective
therapies for advanced disease. Agents blocking the PD-1/PD-L1 pathway have shown …

[HTML][HTML] Polyomavirus-negative Merkel cell carcinoma: a more aggressive subtype based on analysis of 282 cases using multimodal tumor virus detection

AS Moshiri, R Doumani, L Yelistratova, A Blom… - Journal of Investigative …, 2017 - Elsevier
Previous studies have reached conflicting conclusions regarding the proportion of Merkel
cell carcinomas (MCCs) that contain the Merkel cell polyomavirus (MCPyV) and the clinical …

[HTML][HTML] Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline

C Lebbe, JC Becker, JJ Grob, J Malvehy… - European journal of …, 2015 - Elsevier
Merkel cell carcinoma (MCC) is a rare tumour of the skin of neuro-endocrine origin probably
develo** from neuronal mechanoreceptors. A collaborative group of multidisciplinary …

A cornucopia of human polyomaviruses

JA DeCaprio, RL Garcea - Nature reviews Microbiology, 2013 - nature.com
During the past 6 years, focused virus hunting has led to the discovery of nine new human
polyomaviruses, including Merkel cell polyomavirus, which has been linked to Merkel cell …