Major depressive disorder (MDD) was previously hypothesized to be a disease of
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …

Major depressive disorder is a debilitating disorder affecting millions of people each year.
Brain-derived neurotrophic factor (BDNF) and inflammation are two prominent biologic risk …

Objective Amongst psychiatric disorders, major depressive disorder (MDD) is the most
prevalent, by affecting approximately 15–17% of the population and showing a high suicide …

Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …

Brain derived neurotrophic factor (BDNF) has multiple biological functions which are
mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor …

Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …

Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

The suicide death toll is alarmingly high, outnumbering deaths from war and homicide
worldwide (1). Many factors contribute to suicide death, making it difficult to prevent because …

Depression is a multicausal disorder and has been associated with the risk to develop
cancer, dementia, diabetes, epilepsy and stroke. As a metabolic disorder depression has …

Several clinical studies on major depressive disorder (MDD) have shown that blood brain-
derived neurotrophic factor (BDNF)–a factor used to index neuroplasticity–is associated with …