ZBP1 has been characterized as a critical innate immune sensor of not only viral RNA
products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced …

Influenza A viruses (IAVs) possess a great zoonotic potential as they are able to infect
different avian and mammalian animal hosts, from which they can be transmitted to humans …

Abstract The Influenza Research Database (IRD) is a US National Institute of Allergy and
Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to …

Avian influenza viruses (AIVs) circulate globally, spilling over into domestic poultry and
causing zoonotic infections in humans. Fortunately, AIVs are not yet capable of causing …

The recent research findings on influenza A virus (IAV) genome biology prompted us to
present a comprehensive overview of IAV genes, protein functions, and replication cycle …

Influenza virus infections pose a significant threat to public health due to annual seasonal
epidemics and occasional pandemics. Influenza is also associated with significant economic …

Autophagy recycles cellular components and defends cells against intracellular pathogens.
While viruses must evade autophagocytic destruction, some viruses can also subvert …

Influenza A virus infections in humans generally cause self-limited infections, but can result
in severe disease, secondary bacterial pneumonias, and death. Influenza viruses can …

The influenza A virus was isolated for the first time in 1931, and the first attempts to develop
a vaccine against the virus began soon afterwards. In addition to causing seasonal …

The successful isolation of a human influenza virus in 1933 was soon followed by the first
attempts to develop an influenza vaccine. Nowadays, vaccination is still the most effective …