In tissue engineering and regenerative medicine, a biomaterial provides mechanical support
and biochemical signals to encourage cell attachment and modulate cell behaviour …

Valvular heart disease is a major cause of morbidity and mortality worldwide. Surgical valve
repair or replacement has been the standard of care for patients with valvular heart disease …

Biomaterials have played an increasingly prominent role in the success of biomedical
devices and in the development of tissue engineering, which seeks to unlock the …

Regenerative strategies such as stem cell-based therapies and tissue engineering
applications are being developed with the aim to replace, remodel, regenerate or support …

BACKGROUND Vascular replacement and repair for the treatment of atherosclerotic
disease, infection, and traumatic injury are some of the most commonly performed surgical …

Natural biomaterials are extensively used in tissue engineering due to their microstructure
interconnectivity and inherent bioactivity which mimics of natural extracellular matrix (ECM) …

Heart valves are characterized to be highly flexible yet tough, and exhibit complex
deformation characteristics such as nonlinearity, anisotropy, and viscoelasticity, which are …

Cell-derived extracellular matrices (CD-ECMs) captured increasing attention since the first
studies in the 1980s. The biological resemblance of CD-ECMs to their in vivo counterparts …

The creation of a living heart valve is a much-wanted alternative for current valve prostheses
that suffer from limited durability and thromboembolic complications. Current strategies to …

Cardiovascular diseases are the leading cause of global mortality. Over the past two
decades, researchers have tried to provide novel solutions for end-stage heart failure to …