Ligand-gated ion channels: new insights into neurological disorders and ligand recognition
1. INTRODUCTION Ligand-gated ion channels (LGICs) mediate intercellular communication
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …
GABAA receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation
RW Olsen, GD Li - Canadian Journal of Anaesthesia, 2010 - pmc.ncbi.nlm.nih.gov
Purpose The purpose of this review is to summarize current knowledge of detailed
biochemical evidence for the role of γ-aminobutyric acid type A receptors (GABAA–Rs) in the …
biochemical evidence for the role of γ-aminobutyric acid type A receptors (GABAA–Rs) in the …
Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands
Benzodiazepines exert their anxiolytic, anticonvulsant, muscle-relaxant and sedative-
hypnotic properties by allosterically enhancing the action of GABA at GABAA receptors via …
hypnotic properties by allosterically enhancing the action of GABA at GABAA receptors via …
Structural Requirements for Eszopiclone and Zolpidem Binding to the γ-Aminobutyric Acid Type-A (GABAA) Receptor Are Different
SM Hanson, EV Morlock, KA Satyshur… - Journal of medicinal …, 2008 - ACS Publications
The sleep-aids zolpidem and eszopiclone exert their effects by binding to and modulating γ-
aminobutyric acid type-A receptors (GABAARs), but little is known about the structural …
aminobutyric acid type-A receptors (GABAARs), but little is known about the structural …
A Unified Model of the GABAA Receptor Comprising Agonist and Benzodiazepine Binding Sites
R Bergmann, K Kongsbak, PL Sørensen, T Sander… - PloS one, 2013 - journals.plos.org
We present a full-length α1β2γ2 GABA receptor model optimized for agonists and
benzodiazepine (BZD) allosteric modulators. We propose binding hypotheses for the …
benzodiazepine (BZD) allosteric modulators. We propose binding hypotheses for the …
The GABAA receptor α+ β− interface: a novel target for subtype selective drugs
J Ramerstorfer, R Furtmüller… - Journal of …, 2011 - Soc Neuroscience
GABAA receptors mediate the action of many clinically important drugs interacting with
different binding sites. For some potential binding sites, no interacting drugs have yet been …
different binding sites. For some potential binding sites, no interacting drugs have yet been …
Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the κ-opioid …
F Yan, RV Bikbulatov, V Mocanu, N Dicheva… - Biochemistry, 2009 - ACS Publications
Salvinorin A, the most potent naturally occurring hallucinogen, has attracted an increasing
amount of attention since the κ-opioid receptor (KOR) was identified as its principal …
amount of attention since the κ-opioid receptor (KOR) was identified as its principal …
Investigation of [3H]diazepam derivatives as allosteric modulators of GABAA receptor α1β2γ2 subtypes: combination of molecular docking/dynamic simulations …
In this paper, a data set of [3H] diazepam derivatives was analyzed using various
computational methods: molecular docking/dynamic simulations, and QSAR analysis. The …
computational methods: molecular docking/dynamic simulations, and QSAR analysis. The …
Developmental toxicity of procymidone to larval zebrafish based on physiological and transcriptomic analysis
A Wu, Q Yu, H Lu, Z Lou, Y Zhao, T Luo, Z Fu… - … and Physiology Part C …, 2021 - Elsevier
As a broad-spectrum with low toxicity, procymidone (PCM), is widely used in agriculture and
frequently observed in aquatic system, which may cause some impacts on aquatic …
frequently observed in aquatic system, which may cause some impacts on aquatic …
Synthesis, anticonvulsant screening, and molecular modeling studies of new arylalkylimidazole oxime ether derivatives
In this study, 15 new oxime ether derivatives were synthesized and their anticonvulsant
activities were screened in vivo. The compounds were synthesized by the reaction of various …
activities were screened in vivo. The compounds were synthesized by the reaction of various …