Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …

The ubiquitin proteasomal system (UPS) represents a highly regulated protein degradation
pathway essential for maintaining cellular homeostasis. This system plays a critical role in …

Abstract Aberrant DNA/RNA hybrids (R-loops) formed during transcription and replication
disturbances pose threats to genome stability. DHX9 is an RNA helicase involved in R-loop …

Highlights•Genome sequencing has made personalized therapy the preferred cancer
therapeutic approach.•In the past decade, the relevance of targeting DDR kinases for cancer …

Chromosome 17p13. 3 is a region of genomic instability that is linked to different rare
neurodevelopmental genetic diseases, depending on whether a deletion or duplication of …

DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions. To protect genomic
stability and ensure cell homeostasis, cells mount a complex signaling-based response that …

The cell cycle checkpoint kinase Mec1ATR and its integral partner Ddc2ATRIP are vital for
the DNA damage and replication stress response. Mec1–Ddc2 “senses” single-stranded …

The ATR kinase is crucial for genome maintenance, but the mechanisms by which ATR
controls the DNA repair machinery are not fully understood. Here, we find that long-term …

Simple Summary Genomic instability is a major driving force of tumour development and
evolution. Cells have developed sophisticated regulatory systems to preserve the stability of …

Premature telomere shortening or telomere instability is associated with a group of rare and
heterogeneous diseases collectively known as telomere biology disorders (TBDs). Here we …