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Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment
Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …
Epigenetic dysregulation in endometriosis: implications for pathophysiology and therapeutics
Endometriosis is a prevalent gynecological condition associated with pelvic pain and
infertility. Despite more than a century of research, the etiology of endometriosis still eludes …
infertility. Despite more than a century of research, the etiology of endometriosis still eludes …
Causality-enriched epigenetic age uncouples damage and adaptation
Abstract Machine learning models based on DNA methylation data can predict biological
age but often lack causal insights. By harnessing large-scale genetic data through …
age but often lack causal insights. By harnessing large-scale genetic data through …
[HTML][HTML] Molecular and cellular insights into the development of uterine fibroids
Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …
Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation
Uterine leiomyoma is the most common tumor in women and causes severe morbidity in 15
to 30% of reproductive-age women. Epidemiological studies consistently indicate a …
to 30% of reproductive-age women. Epidemiological studies consistently indicate a …
The role of endocrine-disrupting chemicals in uterine fibroid pathogenesis
MV Bariani, R Rangaswamy, H Siblini… - Current Opinion in …, 2020 - journals.lww.com
While research on EDCs and fibroids is still evolving, recent evidence suggests EDC
exposures may contribute to fibroid risk and progression. Further research is needed to …
exposures may contribute to fibroid risk and progression. Further research is needed to …
Epigenomic and enhancer dysregulation in uterine leiomyomas
OW Mlodawska, P Saini, JB Parker… - Human …, 2022 - academic.oup.com
BACKGROUND Uterine leiomyomas, also known as uterine fibroids or myomas, are the
most common benign gynecological tumors and are found in women of reproductive and …
most common benign gynecological tumors and are found in women of reproductive and …
Deficient H2A. Z deposition is associated with genesis of uterine leiomyoma
DG Berta, H Kuisma, N Välimäki, M Räisänen, M Jäntti… - Nature, 2021 - nature.com
One in four women suffers from uterine leiomyomas (ULs)—benign tumours of the uterine
wall, also known as uterine fibroids—at some point in premenopausal life. ULs can cause …
wall, also known as uterine fibroids—at some point in premenopausal life. ULs can cause …
A view on uterine leiomyoma genesis through the prism of genetic, epigenetic and cellular heterogeneity
AS Koltsova, OA Efimova, AA Pendina - International journal of molecular …, 2023 - mdpi.com
Uterine leiomyomas (ULs), frequent benign tumours of the female reproductive tract, are
associated with a range of symptoms and significant morbidity. Despite extensive research …
associated with a range of symptoms and significant morbidity. Despite extensive research …
Integrating intersectionality into the exposome paradigm: a novel approach to racial inequities in uterine fibroids
Intersectionality is a critical theoretical framework that emphasizes the influence of
intersecting systems of oppression on the lived experiences of people marginalized by …
intersecting systems of oppression on the lived experiences of people marginalized by …