Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment

Q Yang, M Ciebiera, MV Bariani, M Ali… - Endocrine …, 2022 - academic.oup.com
Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …

Epigenetic dysregulation in endometriosis: implications for pathophysiology and therapeutics

RM Marquardt, DN Tran, BA Lessey… - Endocrine …, 2023 - academic.oup.com
Endometriosis is a prevalent gynecological condition associated with pelvic pain and
infertility. Despite more than a century of research, the etiology of endometriosis still eludes …

Causality-enriched epigenetic age uncouples damage and adaptation

K Ying, H Liu, AE Tarkhov, MC Sadler, AT Lu, M Moqri… - Nature aging, 2024 - nature.com
Abstract Machine learning models based on DNA methylation data can predict biological
age but often lack causal insights. By harnessing large-scale genetic data through …

[HTML][HTML] Molecular and cellular insights into the development of uterine fibroids

A Machado-Lopez, C Simón, A Mas - International journal of molecular …, 2021 - mdpi.com
Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …

Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation

T Iizuka, P Yin, A Zuberi, S Kujawa, JS Coon… - Proceedings of the …, 2022 - pnas.org
Uterine leiomyoma is the most common tumor in women and causes severe morbidity in 15
to 30% of reproductive-age women. Epidemiological studies consistently indicate a …

The role of endocrine-disrupting chemicals in uterine fibroid pathogenesis

MV Bariani, R Rangaswamy, H Siblini… - Current Opinion in …, 2020 - journals.lww.com
While research on EDCs and fibroids is still evolving, recent evidence suggests EDC
exposures may contribute to fibroid risk and progression. Further research is needed to …

Epigenomic and enhancer dysregulation in uterine leiomyomas

OW Mlodawska, P Saini, JB Parker… - Human …, 2022 - academic.oup.com
BACKGROUND Uterine leiomyomas, also known as uterine fibroids or myomas, are the
most common benign gynecological tumors and are found in women of reproductive and …

Deficient H2A. Z deposition is associated with genesis of uterine leiomyoma

DG Berta, H Kuisma, N Välimäki, M Räisänen, M Jäntti… - Nature, 2021 - nature.com
One in four women suffers from uterine leiomyomas (ULs)—benign tumours of the uterine
wall, also known as uterine fibroids—at some point in premenopausal life. ULs can cause …

A view on uterine leiomyoma genesis through the prism of genetic, epigenetic and cellular heterogeneity

AS Koltsova, OA Efimova, AA Pendina - International journal of molecular …, 2023 - mdpi.com
Uterine leiomyomas (ULs), frequent benign tumours of the female reproductive tract, are
associated with a range of symptoms and significant morbidity. Despite extensive research …

Integrating intersectionality into the exposome paradigm: a novel approach to racial inequities in uterine fibroids

AR Zota, BN VanNoy - American Journal of Public Health, 2021 - ajph.aphapublications.org
Intersectionality is a critical theoretical framework that emphasizes the influence of
intersecting systems of oppression on the lived experiences of people marginalized by …