Intracerebral hemorrhage (ICH) accounts for about 10% of all strokes in the United States of
America causing a high degree of disability and mortality. There is initial (primary) brain …

During atherosclerosis, the gradual accumulation of lipids into the subendothelial space of
damaged arteries results in several lipid modification processes followed by macrophage …

Tumor-associated macrophages are an abundant cell type in the tumor microenvironment.
These macrophages serve as a promising target for treatment of cancer due to their roles in …

The engulfment of apoptotic cells by phagocytes, a process referred to as efferocytosis, is
essential for maintenance of normal tissue homeostasis and a prerequisite for the resolution …

Mer tyrosine kinase (MerTK) is a major macrophage apoptotic cell (AC) receptor. Its
functional impairment promotes autoimmunity and atherosclerosis, whereas overexpression …

Microbial stimuli such as lipopolysaccharide (LPS) induce robust metabolic rewiring in
immune cells known as the Warburg effect. It is unknown whether this increase in glycolysis …

The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important
role in the control of gene expression linked to a variety of physiological processes. PPARγ …

Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

After ischemic stroke, various damage-associated molecules are released from the ischemic
core and diffuse to the ischemic penumbra, activating microglia and promoting …

Members of the nuclear receptor superfamily of ligand-dependent transcription factors
regulate diverse aspects of immunity and inflammation by both positively and negatively …