Semantic memory and language dysfunction in early Alzheimer's disease: a review
M Verma, RJ Howard - International journal of geriatric …, 2012 - Wiley Online Library
Background Language impairment in Alzheimer's disease occurs early, and language
function deteriorates with progression of the illness to cause significant disability. This …
function deteriorates with progression of the illness to cause significant disability. This …
The apolipoprotein e antagonistic pleiotropy hypothesis: review and recommendations
ER Tuminello, SD Han - International journal of Alzheimer's …, 2011 - Wiley Online Library
Research on apolipoprotein E (APOE) has consistently revealed a relationship between the
gene′ s ε4 allele and risk for development of Alzheimer′ s disease (AD). However …
gene′ s ε4 allele and risk for development of Alzheimer′ s disease (AD). However …
Reduced grid-cell–like representations in adults at genetic risk for Alzheimer's disease
Alzheimer's disease (AD) manifests with memory loss and spatial disorientation. AD
pathology starts in the entorhinal cortex, making it likely that local neural correlates of spatial …
pathology starts in the entorhinal cortex, making it likely that local neural correlates of spatial …
Transcranial direct current stimulation in mild cognitive impairment: behavioral effects and neural mechanisms
Introduction The long preclinical phase of Alzheimer's disease provides opportunities for
potential disease-modifying interventions in prodromal stages such as mild cognitive …
potential disease-modifying interventions in prodromal stages such as mild cognitive …
Interaction of age and APOE genotype on cerebral blood flow at rest
CE Wierenga, LR Clark, SI Dev… - Journal of …, 2013 - content.iospress.com
We investigated the impact of APOE genotype on cerebral blood flow (CBF) in older and
younger adults. Forty cognitively normal older adults (16 ε4 carriers, 24 non-ε4 carriers) and …
younger adults. Forty cognitively normal older adults (16 ε4 carriers, 24 non-ε4 carriers) and …
Speech silence character as a diagnostic biomarker of early cognitive decline and its functional mechanism: a multicenter cross-sectional cohort study
Background Language deficits frequently occur during the prodromal stages of Alzheimer's
disease (AD). However, the characteristics of linguistic impairment and its underlying …
disease (AD). However, the characteristics of linguistic impairment and its underlying …
Executive and language subjective cognitive decline complaints discriminate preclinical Alzheimer's disease from normal aging
N Valech, A Tort-Merino… - Journal of …, 2017 - journals.sagepub.com
Background: There is a need to specify the profile of subjective cognitive decline in
preclinical Alzheimer's disease (preAD). Objectives: To explore specific items of the …
preclinical Alzheimer's disease (preAD). Objectives: To explore specific items of the …
Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans
The apolipoprotein (APOE) ε4 allele has been proposed as an example of an antagonistic
pleiotropy gene, conferring a beneficial effect on cognition in early life and a detrimental …
pleiotropy gene, conferring a beneficial effect on cognition in early life and a detrimental …
A systematic review of type 2 diabetes mellitus and hypertension in imaging studies of cognitive aging: time to establish new norms
The rising prevalence of type 2 diabetes (T2DM) and hypertension in older adults, and the
deleterious effect of these conditions on cerebrovascular and brain health, is creating a …
deleterious effect of these conditions on cerebrovascular and brain health, is creating a …
The APOE ɛ4 allele affects complexity and functional connectivity of resting brain activity in healthy adults
The apolipoprotein E (APOE) gene is associated with structural and functional brain
changes. We have used multiscale entropy (MSE) analysis to detect changes in the …
changes. We have used multiscale entropy (MSE) analysis to detect changes in the …