Interpretation of OCT and OCTA images from a histological approach: clinical and experimental implications
Optical coherence tomography (OCT) and OCT angiography (OCTA) have been a
technological breakthrough in the diagnosis, treatment, and follow-up of many retinal …
technological breakthrough in the diagnosis, treatment, and follow-up of many retinal …
Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration
Age-related macular degeneration (AMD) is the major cause of blindness in developed
nations. AMD is characterized by retinal pigmented epithelial (RPE) cell dysfunction and …
nations. AMD is characterized by retinal pigmented epithelial (RPE) cell dysfunction and …
Serotonin in retina
J Masson - Biochimie, 2019 - Elsevier
The expression of serotonin (5-HT) in the retina was first reported in the sixties. The
detection of vesicular monoamine transporter and serotonin receptors in several retinal cells …
detection of vesicular monoamine transporter and serotonin receptors in several retinal cells …
Buspirone Enhances Cell Survival and Preserves Structural Integrity during Oxidative Injury to the Retinal Pigment Epithelium
Chronic oxidative stress impairs the normal functioning of the retinal pigment epithelium
(RPE), leading to atrophy of this cell layer in cases of advance age-related macular …
(RPE), leading to atrophy of this cell layer in cases of advance age-related macular …
Modulation of TGF-β/Smad and ERK signaling pathways mediates the anti-fibrotic effect of mirtazapine in mice
Abstract Serotonin (5-HT) has been implicated as a key driver of liver fibrosis, acting via 5-
HT2 receptor activation in the hepatic stellate cells. The current study was conducted to …
HT2 receptor activation in the hepatic stellate cells. The current study was conducted to …
Glycative stress as a cause of macular degeneration
E Bejarano, A Domenech-Bendaña… - Progress in Retinal and …, 2024 - Elsevier
People are living longer and rates of age-related diseases such as age-related macular
degeneration (AMD) are accelerating, placing enormous burdens on patients and health …
degeneration (AMD) are accelerating, placing enormous burdens on patients and health …
Monomethyl fumarate protects the retina from light-induced retinopathy
D Jiang, RC Ryals, SJ Huang… - … & Visual Science, 2019 - iovs.arvojournals.org
Purpose: We determine if monomethyl fumarate (MMF) can protect the retina in mice
subjected to light-induced retinopathy (LIR). Methods: Albino BALB/c mice were …
subjected to light-induced retinopathy (LIR). Methods: Albino BALB/c mice were …
Repurposing drugs for treatment of age-related macular degeneration
SG Francisco, S Rowan - Retinal Degenerative Diseases XIX …, 2023 - Springer
The need for new drugs to treat dry forms of age-related macular degeneration remains
high. A promising approach is repurposing of FDA-approved medications to treat AMD …
high. A promising approach is repurposing of FDA-approved medications to treat AMD …
GARP2 accelerates retinal degeneration in rod cGMP-gated cation channel β-subunit knockout mice
ML DeRamus, DA Stacks, Y Zhang, CE Huisingh… - Scientific reports, 2017 - nature.com
The Cngb1 locus-encoded β-subunit of rod cGMP-gated cation channel and associated
glutamic acid rich proteins (GARPs) are required for phototransduction, disk morphogenesis …
glutamic acid rich proteins (GARPs) are required for phototransduction, disk morphogenesis …
Synthesis and Biological Analysis of Iso-dimethyltryptamines in a Model of Light-Induced Retinal Degeneration
Iso-dimethyltryptamine (isoDMT) analogues with heterocyclic substitutions at the indole C
(3) were prepared in a hydrogen autotransfer alkylation and tested in combination with …
(3) were prepared in a hydrogen autotransfer alkylation and tested in combination with …