Resistance threatens to render antibiotics—which are essential for modern medicine—
ineffective, thus posing a threat to human health. The discovery of novel classes of …

Abstract Gram-positive (G+) bacterial infection is a great burden to both healthcare and
community medical resources. As a result of the increasing prevalence of multidrug-resistant …

Endolysins and their derivatives have emerged in recent years as a novel class of
antibacterials, which have now entered the clinical phases. Their rapid mode-of-action and …

Endolysins are the lytic products of bacteriophages which play a specific role in the release
of phage progeny by degrading the peptidoglycan of the host bacterium. In the light of …

Lytic enzymes encoded by bacteriophages have been intensively explored as alternative
agents for combating bacterial pathogens in different contexts. The antibacterial character of …

With widespread abuse of antibiotics, bacterial resistance has increasingly become a
serious threat. Acinetobacter baumannii has emerged as one of the most important hospital …

Lower respiratory tract infections and tuberculosis are responsible for the death of about 4.5
million people each year and are the main causes of mortality in children under 5 years of …

Introduction: In light of the emergence of antibiotic-resistant bacteria, phage (bacteriophage)
therapy has been recognized as a potential alternative or addition to antibiotics in Western …

Multi-drug resistance has called for a race to uncover alternatives to existing antibiotics.
Phage therapy is one of the explored alternatives, including the use of endolysins, which are …

Bacteriophages express endolysins toward the end of their replication cycle to degrade the
microbial cell wall from within, allowing viral progeny to be released. Endolysins can also …