Targeting signalling pathways and the immune microenvironment of cancer stem cells—a clinical update
Cancer stem cells (CSCs) have important roles in tumour development, relapse and
metastasis; the intrinsic self-renewal characteristics and tumorigenic properties of these cells …
metastasis; the intrinsic self-renewal characteristics and tumorigenic properties of these cells …
Antitumour dendritic cell vaccination in a priming and boosting approach
Mobilizing antitumour immunity through vaccination potentially constitutes a powerful
anticancer strategy but has not yet provided robust clinical benefits in large patient …
anticancer strategy but has not yet provided robust clinical benefits in large patient …
[HTML][HTML] Therapeutic potential of CAR T cell in malignancies: A sco** review
Although tremendous advancements in cancer therapy over the last several years, cancer
still is a complex illness to cure. Traditional cancer treatments, including chemotherapy …
still is a complex illness to cure. Traditional cancer treatments, including chemotherapy …
[HTML][HTML] CAR T cell-based immunotherapy for the treatment of glioblastoma
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumor in adults. Current treatment options typically consist of surgery followed by …
tumor in adults. Current treatment options typically consist of surgery followed by …
Mesothelin-targeted CARs: driving T cells to solid tumors
A Morello, M Sadelain, PS Adusumilli - Cancer discovery, 2016 - AACR
Chimeric antigen receptors (CAR) are synthetic receptors that target T cells to cell-surface
antigens and augment T-cell function and persistence. Mesothelin is a cell-surface antigen …
antigens and augment T-cell function and persistence. Mesothelin is a cell-surface antigen …
[HTML][HTML] CAR-T cell therapy for breast cancer: from basic research to clinical application
YH Yang, JW Liu, C Lu, JF Wei - International journal of biological …, 2022 - ncbi.nlm.nih.gov
Breast cancer rises as the most commonly diagnosed cancer in 2020. Among women,
breast cancer ranks first in both cancer incidence rate and mortality. Treatment resistance …
breast cancer ranks first in both cancer incidence rate and mortality. Treatment resistance …
CAR-engineered NK cells for the treatment of glioblastoma: turning innate effectors into precision tools for cancer immunotherapy
Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and
currently incurable. Despite multimodal treatment regimens, median survival in unselected …
currently incurable. Despite multimodal treatment regimens, median survival in unselected …
CAR-T cell therapy in triple-negative breast cancer: Hunting the invisible devil
Triple-negative breast cancer (TNBC) is known as the most intricate and hard-to-treat
subtype of breast cancer. TNBC cells do not express the well-known estrogen receptor …
subtype of breast cancer. TNBC cells do not express the well-known estrogen receptor …
Tumor buster-where will the CAR-T cell therapy 'missile'go?
Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing
technology represents a significant breakthrough in personalized immunotherapy for human …
technology represents a significant breakthrough in personalized immunotherapy for human …
Emerging CAR-T cell therapy for the treatment of triple-negative breast cancer
S Dees, R Ganesan, S Singh, IS Grewal - Molecular cancer therapeutics, 2020 - AACR
Triple-negative breast cancer (TNBC), a highly aggressive breast cancer subtype that lacks
estrogen receptor, progesterone receptor, and HER2 expression, does not respond to …
estrogen receptor, progesterone receptor, and HER2 expression, does not respond to …