Long-term potentiation of synaptic transmission in the hippocampus is the primary
experimental model for investigating the synaptic basis of learning and memory in …

Lynch, MA. Long-Term Potentiation and Memory. Physiol Rev 84: 87–136, 2004;
10.1152/physrev. 00014.2003.—One of the most significant challenges in neuroscience is to …

Repeated stimulation of hippocampal neurons can induce an immediate and prolonged
increase in synaptic strength that is called long-term potentiation (LTP)—the primary cellular …

Unraveling the molecular mechanisms governing long-term synaptic plasticity is a key to
understanding how the brain stores information in neural circuits and adapts to a changing …

Two neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-
3), are able to produce a long-lasting enhancement of synaptic transmission in the …

Polyribosomal complexes beneath postsynaptic sites on dendrites provide a substrate for
local translation of particular mRNAs, but the signals that target mRNAs to synapses remain …

Trans-synaptic activation of gene expression is linked to long-term plastic adaptations in the
nervous system. To examine the molecular program induced by synaptic activity, we have …

Repeated high-frequency trains of stimuli induce long-term potentiation (LTP) in the CA1
region that persists for up to 8 hours in hippocampal slices and for days in intact animals …

A novel property of hippocampal LTP,variable persistence', has recently been described that
is, we argue, relevant to the role of LTP in information storage. Specifically, new results …

Memory and synaptic plasticity exhibit distinct temporal phases, with long-lasting forms
distinguished by their dependence on macromolecular synthesis. Prevailing models for the …