[HTML][HTML] The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy

F Ardito, M Giuliani, D Perrone… - International …, 2017 - spandidos-publications.com
Protein phosphorylation is an important cellular regulatory mechanism as many enzymes
and receptors are activated/deactivated by phosphorylation and dephosphorylation events …

Interplay of calcium and cadmium in mediating cadmium toxicity

G Choong, Y Liu, DM Templeton - Chemico-biological interactions, 2014 - Elsevier
The environmentally important toxic metal, cadmium, exists as the Cd 2+ ion in biological
systems, and in this state structurally resembles Ca 2+. Thus, although cadmium exerts a …

βCaMKII in lateral habenula mediates core symptoms of depression

K Li, T Zhou, L Liao, Z Yang, C Wong, F Henn… - science, 2013 - science.org
The lateral habenula (LHb) has recently emerged as a key brain region in the
pathophysiology of depression. However, the molecular mechanism by which LHb becomes …

Systems vaccinology: probing humanity's diverse immune systems with vaccines

B Pulendran - Proceedings of the National Academy of Sciences, 2014 - pnas.org
Homo sapiens are genetically diverse, but dramatic demographic and socioeconomic
changes during the past century have created further diversification with respect to age …

CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance

T Koga, CM Hedrich, M Mizui, N Yoshida… - The Journal of clinical …, 2014 - jci.org
Tissue inflammation in several autoimmune diseases, including SLE and MS, has been
linked to an imbalance of IL-17–producing Th (Th17) cells and Tregs; however, the factors …

Calcium in health and disease

M Brini, D Ottolini, T Calì, E Carafoli - Interrelations between essential …, 2013 - Springer
Evolution has exploited the chemical properties of Ca 2+, which facilitate its reversible
binding to the sites of irregular geometry offered by biological macromolecules, to select it as …

The KN-93 molecule inhibits calcium/calmodulin-dependent protein kinase II (CaMKII) activity by binding to Ca2+/CaM

MH Wong, AB Samal, M Lee, J Vlach, N Novikov… - Journal of molecular …, 2019 - Elsevier
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional
serine/threonine protein kinase that transmits calcium signals in various cellular processes …

Autoantibody biomarkers for basal ganglia encephalitis in sydenham chorea and pediatric autoimmune neuropsychiatric disorder associated with streptococcal …

JL Chain, K Alvarez, A Mascaro-Blanco, S Reim… - Frontiers in …, 2020 - frontiersin.org
Movement, behavioral, and neuropsychiatric disorders in children have been linked to
infections and a group of anti-neuronal autoantibodies, implying dopamine receptor …

CaMK4 gene deletion induces hypertension

G Santulli, E Cipolletta, D Sorriento… - Journal of the …, 2012 - ahajournals.org
Background The expression of calcium/calmodulin‐dependent kinase IV (CaMKIV) was
hitherto thought to be confined to the nervous system. However, a recent genome‐wide …

[HTML][HTML] Friend and foe: β-cell Ca2+ signaling and the development of diabetes

PV Sabatini, T Speckmann, FC Lynn - Molecular metabolism, 2019 - Elsevier
Abstract Background The divalent cation Calcium (Ca 2+) regulates a wide range of
processes in disparate cell types. Within insulin-producing β-cells, increases in cytosolic Ca …