Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …

Intravenous immunoglobulin (IVIG) is a pooled preparation of normal IgG obtained from
several thousand healthy donors. It is widely used in the immunotherapy of a large number …

Sensitization of the humoral immune response to invading viruses and production of
antiviral antibodies forms part of the host antiviral repertoire. Paradoxically, for a number of …

Intravenous immunoglobulin (IVIg)—a preparation of polyclonal serum IgG pooled from
thousands of blood donors—has been used for nearly three decades, and is proving to be …

Self-reactive IgGs contribute to the pathology of autoimmune diseases, including systemic
lupus erythematosus and rheumatoid arthritis. Paradoxically, IgGs are used to treat …

Immunglobulin G (IgG) sialylation represents a key checkpoint that determines the
engagement of pro-or anti-inflammatory Fcγ receptors (FcγR) and the direction of the …

Abundant evidence points to a critical role for antibodies in protection and pathology across
infectious diseases. While the antibody variable domain facilitates antibody binding and the …

Highlights•Glycosylation of antibodies has a range of effects on their binding and effector
functions.•Regulatory agencies require stringent glycan analysis to ensure safety and …

Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy
of therapeutic antibodies. While the biantennary complex-type oligosaccharide attached to …