Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy
protocols. Severe side effects such as cardiotoxicity, however, limit Dox application …

Grafted mesenchymal stem cells (MSCs) yield neuroprotection in preclinical stroke models
by secreting extracellular vesicles (EVs). The neuroprotective cargo of EVs, however, has …

Mitochondrial dysfunction has been implicated in the pathogenesis of nonalcoholic fatty liver
disease (NAFLD) through poorly defined mechanisms. Melatonin supplementation has been …

Rationale: Autophagy can preserve cell viability under conditions of mild ischemic stress by
degrading damaged organelles for ATP production, but under conditions of severe …

Mitochondrial function is maintained by several strictly coordinated mechanisms, collectively
termed mitochondrial quality control mechanisms, including fusion and fission, degradation …

Cardiovascular disease (CVD) remains the leading cause of mortality globally, so further
investigation is required to identify its underlying mechanisms and potential targets for its …

Autophagy mediates cellular quality control mechanisms and energy homeostasis through
lysosomal degradation. Autophagy is typically viewed as an adaptive process that allows …

Autophagy is an indispensable mechanism of the eukaryotic cell, facilitating the removal and
renewal of cellular components and thereby balancing the cell's energy consumption and …

Abstract p53 is an important tumour suppressor gene, with loss of p53 contributing to the
development of most human cancers. However, the activation of p53 in response to stress …