Tumor microenvironment complexity and therapeutic implications at a glance

R Baghban, L Roshangar… - Cell Communication and …, 2020 - Springer
The dynamic interactions of cancer cells with their microenvironment consisting of stromal
cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to …

Nano-drug delivery system targeting tumor microenvironment: A prospective strategy for melanoma treatment

M Xu, S Li - Cancer Letters, 2023 - Elsevier
Melanoma, the most aggressive form of cutaneous malignancy arising from melanocytes, is
frequently characterized by metastasis. Despite considerable progress in melanoma …

Cancer combination therapies by angiogenesis inhibitors; a comprehensive review

MJ Ansari, D Bokov, A Markov, AT Jalil… - Cell Communication and …, 2022 - Springer
Abnormal vasculature is one of the most conspicuous traits of tumor tissue, largely
contributing to tumor immune evasion. The deregulation mainly arises from the potentiated …

Tumor angiogenesis and anti-angiogenic strategies for cancer treatment

RI Teleanu, C Chircov, AM Grumezescu… - Journal of clinical …, 2019 - mdpi.com
Angiogenesis is the process through which novel blood vessels are formed from pre-existing
ones and it is involved in both physiological and pathological processes of the body …

Resistance mechanisms to anti-angiogenic therapies in cancer

Y Haibe, M Kreidieh, H El Hajj, I Khalifeh… - Frontiers in …, 2020 - frontiersin.org
Tumor growth and metastasis rely on tumor vascular network for the adequate supply of
oxygen and nutrients. Tumor angiogenesis relies on a highly complex program of growth …

Targeting metabolic plasticity and flexibility dynamics for cancer therapy

SM Fendt, C Frezza, A Erez - Cancer discovery, 2020 - aacrjournals.org
Cancer cells continuously rewire their metabolism to fulfill their need for rapid growth and
survival while subject to changes in environmental cues. Thus, a vital component of a cancer …

Alliance with EPR effect: combined strategies to improve the EPR effect in the tumor microenvironment

J Park, Y Choi, H Chang, W Um, JH Ryu… - Theranostics, 2019 - pmc.ncbi.nlm.nih.gov
The use of nanomedicine for cancer treatment takes advantage of its preferential
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …

Angiogenesis in breast cancer progression, diagnosis, and treatment

CO Madu, S Wang, CO Madu, Y Lu - Journal of Cancer, 2020 - pmc.ncbi.nlm.nih.gov
Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This
process frequently involves vasodilation and an increase in vascular permeability …

Advancement in biopolymer assisted cancer theranostics

T Bhattacharya, S Preetam, B Ghosh… - ACS Applied Bio …, 2023 - ACS Publications
Applications of nanotechnology have increased the importance of research and
nanocarriers, which have revolutionized the method of drug delivery to treat several …