Hyperosmotic stress is an often overlooked process that potentially contributes to a number
of human diseases. Whereas renal hyperosmolarity is a well-studied phenomenon, recent …

Degeneration of the intervertebral disc is characterized by changes in proteoglycan status,
loss of bound water molecules, decreased tissue osmotic pressure and a resulting …

OBJECTIVE: Three-dimensional (3D) cultures are widely used to redifferentiate
chondrocytes. However, the rationale behind the choice for 3D above two-dimensional (2D) …

OBJECTIVE: Mesenchymal stem cells (MSCs) are promising candidates for osteoarthritis
(OA) therapies, although their mechanism of action remains unclear. MSCs have recently …

Additively manufactured (AM) degradable porous metallic biomaterials offer unique
opportunities for satisfying the design requirements of an ideal bone substitute. Among the …

Osteoarthritis (OA) is a musculoskeletal disease characterized by progressive degeneration
of osteochondral tissues. Current treatment is restricted to the reduction of pain and loss of …

Mesenchymal stem cells (MSCs) are promising for cartilage regeneration, but readily
undergo terminal differentiation. The aim of this study was two-fold: a) investigate …

The tonicity-responsive enhancer binding protein (TonEBP) plays an important role in
intervertebral disc and axial skeleton embryogenesis. However, the contribution of this …

Introduction Osteoarthritis is, at least in a subset of patients, associated with hypertrophic
differentiation of articular chondrocytes. Recently, we identified the bone morphogenetic …

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the degradation
of joint cartilage, subchondral bone sclerosis, synovitis, and structural changes in the joint …