Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-
protein-coupled seven-span transmembrane receptors, are major regulators of cell …

Chemokines have fundamental roles in regulating immune and inflammatory responses,
primarily through their control of leukocyte migration and localization. The biological …

The stromal cell-derived factor-1/CXCL12 chemokine engages the CXCR4 and CXCR7
receptors and regulates homeostatic and pathologic processes, including organogenesis …

Recent studies implicated the existence in adult human kidney of a population of renal
progenitors with the potential to regenerate glomerular as well as tubular epithelial cells and …

Background CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is
phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and …

G protein-coupled receptor hetero-oligomerization is emerging as an important regulator of
ligand-dependent transmembrane signaling, but precisely how receptor heteromers affect …

Depletion of podocytes, common to glomerular diseases in general, plays a role in the
pathogenesis of glomerulosclerosis. Whether podocyte injury in adulthood can be repaired …

In vitro hypoxic preconditioning (HP) of mesenchymal stem cells (MSCs) could ameliorate
their viability and tissue repair capabilities after transplantation into the injured tissue …

The chemokine CXCL12, also known as stromal cell-derived factor 1 (SDF1), has emerged
as a pivotal regulator in the intricate molecular networks driving cancer progression. As an …

Macrophage migration‐inhibitory factor (MIF) is a pleiotropic cytokine with chemokine‐like
functions and is a mediator in numerous inflammatory conditions. Depending on the context …