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NK cell-based cancer immunotherapy: from basic biology to clinical development
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …
immune activation against abnormal cells. Different from events required for T cell activation …
Cytokine-induced memory-like NK cells: from the basics to clinical applications
Natural killer (NK) cells are lymphocytes with a key role in the defense against viral
infections and tumor cells. Although NK cells are classified as innate lymphoid cells (ILCs) …
infections and tumor cells. Although NK cells are classified as innate lymphoid cells (ILCs) …
Immunotherapy in acute myeloid leukemia: where we stand
In the past few years, our improved knowledge of acute myeloid leukemia (AML)
pathogenesis has led to the accelerated discovery of new drugs and the development of …
pathogenesis has led to the accelerated discovery of new drugs and the development of …
Sha** of Natural Killer Cell Antitumor Activity by Ex Vivo Cultivation
Natural killer (NK) cells are a promising tool for the use in adoptive immunotherapy, since
they efficiently recognize and kill tumor cells. In this context, ex vivo cultivation is an …
they efficiently recognize and kill tumor cells. In this context, ex vivo cultivation is an …
Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity
Natural killer (NK) cells are a major component of the anti-tumor immune response. NK cell
dysfunctions have been reported in various hematologic malignancies, including chronic …
dysfunctions have been reported in various hematologic malignancies, including chronic …
Leukemia-induced phenotypic and functional defects in natural killer cells predict failure to achieve remission in acute myeloid leukemia
K Stringaris, T Sekine, A Khoder, A Alsuliman… - …, 2014 - pmc.ncbi.nlm.nih.gov
The majority of patients with acute myeloid leukemia will relapse, and older patients often
fail to achieve remission with induction chemotherapy. We explored the possibility that …
fail to achieve remission with induction chemotherapy. We explored the possibility that …
[HTML][HTML] Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells
The activity of natural killer (NK) cells is regulated by surface receptors, which direct target
cell recognition. NKp30 (Natural Cytotoxicity Receptor 3) induces target cell lysis and is also …
cell recognition. NKp30 (Natural Cytotoxicity Receptor 3) induces target cell lysis and is also …
Clinical utility of natural killer cells in cancer therapy and transplantation
Natural killer (NK) cells recognize deranged cells that display stress receptors or loss of
major histocompatibility complex (MHC) class I. During development, NK cells become …
major histocompatibility complex (MHC) class I. During development, NK cells become …
Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function
NKp30, a natural cytotoxicity receptor expressed on NK cells is critically involved in direct
cytotoxicity against various tumor cells and directs both maturation and selective killing of …
cytotoxicity against various tumor cells and directs both maturation and selective killing of …
Targeting CD20+ Aggressive B-cell Non–Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells In Vitro and in NSG Mice
Y Chu, J Hochberg, A Yahr, J Ayello… - Cancer immunology …, 2015 - aacrjournals.org
The prognosis is very dismal for patients with relapsed CD20+ B-cell non-Hodgkin
lymphoma (B-NHL). Facilitating the development of alternative novel therapeutic strategies …
lymphoma (B-NHL). Facilitating the development of alternative novel therapeutic strategies …